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8402411 
Journal Article 
Antistressornoe deǐstvie dibunola pri operatsionnom stress u bol'nykh rakom legkogo 
Baraboç, VA; Bororov, LV; Gunina, LM; Maevskaia, LP 
1994 
Yes 
Eksperimental'naya i Klinicheskaya Farmakologiya
ISSN: 0869-2092 
57 
5 
43-45 
Russian 
Dibunol (butylhydroxytoluene) in 1-g capsules was given to lung cancer patients, 4 g for two days and 4 g for one day before surgery. The level of stress was evaluated by the blood levels of cortisole, by the daily urinary concentrations of 17-keto- and 17-ketogenic steroids, and by the blood levels medium-weight molecular peptides and toxic indices 1, 3, 5-7 days of postsurgery. The antistress action of the agent appeared as twofold decreased blood cortisol and urinary 17-KS and 17-KGS 1 day after surgery, returning to the baseline on day 3 (while there was no normalization even on day 7 if dibunol was not given), and as significantly declined intoxication indices.