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HERO ID
8403832
Reference Type
Journal Article
Title
Resveratrol improved hippocampal neurogenesis following lead exposure in rats through activation of SIRT1 signaling
Author(s)
Wang, R; Wu, Z; Bai, L; Liu, R; Ba, Y; Zhang, H; Cheng, X; Zhou, G; Huang, H
Year
2021
Is Peer Reviewed?
Yes
Journal
Environmental Toxicology
ISSN:
1520-4081
EISSN:
1522-7278
Volume
36
Issue
8
Page Numbers
1664-1673
Language
English
PMID
33978298
DOI
10.1002/tox.23162
Web of Science Id
WOS:000649382300001
URL
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105614975&doi=10.1002%2ftox.23162&partnerID=40&md5=c73a1678d78c3bf84ce3fb8ccdd683cb
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Abstract
Lead (Pb) poses a potential environmental risk factor for cognitive dysfunction during early life and childhood. Resveratrol is considered a promising antioxidant with respect to the prevention of cognitive deficits and act as a potent SIRT1 agonist. Herein, this study aims to investigate the profile of neurogenesis markers following Pb exposure and to determine the regulatory role of resveratrol in this process. We confirmed firstly the protective effects of resveratrol against Pb-induced impairments of hippocampal neurogenesis in Male SD rats. Pb exposure early in life caused the altered expression of Ki-67, NeuN, caspase-3 and SIRT1 signaling, thereby resulting in spatial cognitive impairment of adolescent rats. As expected, resveratrol reduced cognitive damage and promoted neurogenesis in Pb-induced injury by regulation of SIRT1 pathway. Collectively, our study establishes the efficacy of resveratrol as a neuroprotective agent and provides a strong rationale for further studies on SIRT1-mediated mechanisms of neuroprotective functions.
Keywords
SIRT1; lead; learning and memory; neurogenesis; resveratrol
Tags
NAAQS
•
ISA - Lead (2024 Final Project Page)
Included in External Review Draft
Appendix 3 (Nervous System Effects)
Included in Final Draft
Appendix 3 (Nervous System Effects)
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