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8405829 
Journal Article 
On the role of polarizability in QSAR 
Verma, RP; Kurup, A; Hansch, C 
2005 
Yes 
Bioorganic & Medicinal Chemistry
ISSN: 0968-0896
EISSN: 1464-3391 
13 
1 
237-255 
English 
The QSAR model for the polarizability effects on ligand-substrate interactions can be illustrated in terms of NVE (number of valence electrons) by Eq. I.log1/C=a(NVE)±constant The polarizability of a molecule, an important physical property, is currently attracting our attention particularly in the area of QSAR for chemical-biological interactions. In this report, the polarizability effects on ligand-substrate interactions has been discussed in terms of NVE (number of valence electrons) using additive values for valence electrons and the formulation of a total number of 51 QSAR. The QSAR model can be illustrated by Eq. I.log1/C=a(NVE)±constant © 2004 Elsevier Ltd. All rights reserved. 
Chemical-biological interaction; Enzymes; NVE; Polarizability; QSAR; Receptors