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8428 
Journal Article 
An outbleak of acute arsenic poisoning caused by arsenic contaminated soy-sauce (shoyu): a clinical report of 220 caces 
Mizuta, N; Mizuta, M; Ito, F; Ito, T; Uchida, H; Watanabe, Y; Akama, H; Murakami, T; Hayashi, F; Nakamura, K; Yamaguchi, T; Mizuia, W; Oishi, S; Matsumura, H 
1956 
0 
Bulletin of the Yamaguchi Medical School
ISSN: 0513-1812 
4 
2-3 
131-150 
At the beginning ofJanuary 1956, a~ outbreak of acute poisoning due to soysauce
(shoyu) accidentally contaminated by arsenic (probably calcium arsenate)
has occurred in the city of Ube, Yamaguchi Prefecture. Fortunately, the number of the patients was limited to 417 with no mortality owing to the early recognition of the true nature of the poisoning and immediate effective preventive procedures that were taken. We wish to report the clinical picture of 220 cases, the majority of which showed symptoms that was somewhat diflerent from those appearing in the literature.
Another peculiarity of this series is that the arsenic was contained in soy-sauce. The arsenic content of the soy-sauce which caused this accident was estimated to be about 0.1 mg per milliliter.