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8428510 
Journal Article 
Coenzyme a: PKa and γ values 
Pitman, IH; Morris, IJ 
1980 
Yes 
Australian Journal of Chemistry
ISSN: 0004-9425
EISSN: 1445-0038 
33 
7 
1625-1630 
English 
The pKa and γ values at 25°, I 0·1 m, of the mercapto group of coenzyme A were calculated to be 10·35 ± 0·15 and 0·70 ± 0·02 respectively. The γ value was calculated from differences in the partition coefficient of quinazoline between cyclohexane and aqueous buffers and that between cyclo- hexane and aqueous buffers which contained coenzyme A. The described procedure could be used to obtain γ values of other nucleophilic reagents which, like coenzyme A, absorb u.v. energy strongly. © 1980 ASEG.