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8436916 
Journal Article 
Greener" Synthesis of Zoledronic Acid from Imidazol-1-yl-acetic Acid and P-Reagents Using Diethyl Carbonate as the Solvent Component 
Grun, A; Szalai, Z; Keglevich, G; , 
2021 
1 
Letters in Organic Chemistry
ISSN: 1570-1786 
BENTHAM SCIENCE PUBL LTD 
SHARJAH 
8-12 
WOS:000631152000003 
The synthesis of a third generation dronic acid, zoledronic acid by the reaction of imidazol-1-yl-acetic acid with phosphorus trichloride/phosphorous acid in diethyl carbonate (DEC) as a "green" solvent, and in DEC - methanesulfonic acid (MSA) solvent mixtures is described. The earlier not "green" and expensive MSA and sulfolane solvents may be replaced by DEC.