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Citation
Tags
HERO ID
8442611
Reference Type
Journal Article
Title
Molecular pathways and therapeutic targets in lung cancer
Author(s)
Shtivelman, E; Hensing, T; Simon, GR; Dennis, PA; Otterson, GA; Bueno, R; Salgia, R
Year
2014
Is Peer Reviewed?
1
Journal
Oncotarget
ISSN:
1949-2553
Publisher
Impact Journals LLC
Volume
5
Issue
6
Page Numbers
1392-1433
Language
English
DOI
10.18632/oncotarget.1891
Abstract
Lung cancer is still the leading cause of cancer death worldwide. Both histologically and molecularly lung cancer is heterogeneous. This review summarizes the current knowledge of the pathways involved in the various types of lung cancer with an emphasis on the clinical implications of the increasing number of actionable molecular targets. It describes the major pathways and molecular alterations implicated in the development and progression of non-small cell lung cancer (adenocarcinoma and squamous cancer), and of small cell carcinoma, emphasizing the molecular alterations comprising the specific blueprints in each group. The approved and investigational targeted therapies as well as the immune therapies, and clinical trials exploring the variety of targeted approaches to treatment of lung cancer are the main focus of this review.
Keywords
Immune therapy; Lung cancer; Targeted therapy
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