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8443782 
Journal Article 
水相中可见光下苯甲醇氧化合成喹唑啉酮衍生物的研究 
Zhang, F; Hou, H; Xu, X; Chen, Z; Ke, F 
2021 
1 
Youji Huaxue / Chinese Journal of Organic Chemistry
ISSN: 0253-2786 
Science Press 
41 
2 
833-841 
Chinese 
A novel visible-light-introduced reaction for the construction of quinazolinone derivatives via radical cyclization of 2-aminobenzamides with benzyl alochols under water phase has been developed. The reaction has been achieved in high yield under mild conditions by using I2 as photocatalyst, which is cheap, available and easy to handle. A variety of quinazolinones were obtained in yields up to 92%. It might provide a promising protocol for the synthesis of quinazolinone derivatives. Its application was performed by the synthesis of N-(2-fluoro-5-methylphenyl)-6-(2, 2, 2-trifluoroethoxy)pteridin-4-amine, which displayed significant inhibitory activity. © 2021 Chinese Chemical Society & SIOC, CAS. 
Catalyst; Iodine; Oxidant; Quinazolinone; Visible light