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8455964 
Journal Article 
Antitumor-promoting activity of allixin, a stress compound produced by garlic 
Nishino, H; Nishino, A; Takayasu, J; Iwashima, A; Itakura, Y; Kodera, Y; Matsuura, H; Fuwa, T 
1990 
1 
The Cancer Journal
ISSN: 1528-9117 
3 
1 
20-21 
English 
Since a protective effect of garlic on human cancer, as well as on experimental animal tumors, has been reported, it is worthwhile surveying anti-carcinogenic principles in garlic. In this study, we proved the antitumor-promoting activity of allixin, which was recently identified as a stress compound produced by garlic. Firstly, allixin was found to be promising in the in vitro test of screening for antitumor-promoter activity; allixin inhibited the enhanced phospholipid metabolism of cultured cells induced by a tumor promotor, 2-O-tetradecanoylphorbol-13-acetate (TPA). Furthermore, allixin was proved to suppress the promoting process of two-stage carcinogenesis in vivo; allixin suppressed the promoting activity of TPA on skin tumor formation in 7,12-dimethylbenz(a)anthracene-initiated mice. Since allixin seems to have no side effects, it may be useful for prevention of human cancer.