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8459283 
Journal Article 
Cardiovascular effects of preparation CIBA 34,276-Ba and imipramine 
Brunner, H; Hedwall, PR; Meier, M; Bein, HJ 
1971 
1 
Agents and Actions
ISSN: 0065-4299 
Birkhäuser-Verlag 
2 
2 
69-82 
English 
The cardiovascular effects of compound CIBA 34,276-Ba and imipramine were compared. In the conscious dog, intravenous infusion or oral administration of compond CIBA 34,276-Ba had only a slight effect on blood pressure and heart rate, whereas the intravenous administration of imipramine gave rise to clearcut tachycardia and did not influence blood pressure. In dogs anaesthetized with chloralose, compound CIBA 34,276-Ba reduced blood pressure and heart rate slightly, diminished cardiac output when given in high doses and increased total peripheral resistance. Imipramine administered in the same doses had no effect on blood pressure, increased heart rate and led to qualitatively similar but quantitatively more pronounced changes in cardiac output and peripheral resistance than compound CIBA 34,276-Ba. In cats anaesthetized with allobarbitone, compound CIBA 34,276-Ba and imipramine in doses up to 3 mg/kg i.v. had only a slight effect on blood pressure, contractile force and heart rate. A negative inotropic effect was evident after intravenous administration of 3 mg/kg imipramine. In the isolated guinea-pig atrium imipramine increased cardiac contractile force in a concentration of 1 mcg/ml, while both compounds displayed a cardiodepressant effect with 10 mcg/ml. In conscious renal hypertensive rats, both compounds had no effect on blood pressure, but reduced blood pressure in the same animals anaesthetized with ether. © 1971 Birkhäuser Verlag.