US EPA

8469170 

Journal Article 

A novel biphasic electrolysis method for the oxidation of 4-methylbenzyl alcohol by in-situ generated hypochlorous acid using nacl as electro catalytic mediator 

John Bosco, A; Lawrence, S; Christopher, C; Bala, M; Easuraja, M; Raja, S 

2013 

1 

International Journal of Pharmacy and Pharmaceutical Sciences
ISSN: 2656-0097
EISSN: 0975-1491 

5 

SUPPL. 2 

531-535 

English 

Objective: The objective of the present work is to investigatethe electrochemical oxidation of 4-methylbenzylalcohol to4-methylbenzaldehyde in the presence of water soluble electrocatalytic mediator sodium chloride with newly generated hypochlorous reactive species by biphasic electrolysis system. Methods: Optimization studies have been carried out on an undivided beaker-type cell. The various parameters of 4- methylbenzyl alcohol influencing the reactions such as current density, mediator, acid and solvent have been investigated.Comparative study has been carried out for chemical and electrochemical method. Results: The Chloride containing mediator showed 96% yield of 4-methylbenzaldehyde under biphasic electrolysis. HPLC analysis confirms the existence of High quality of the yield. The plausible mechanism for the chloride oxidation system is shown in scheme 2. Conclusion: The electrolysis was carried out with the passage 3F of electricity which showed the good yield of 96%4-methylbenzaldehyde may serve as a leads for further optimization. 

4-methylbenzylalcohol; Biphasic electrolysis; Chloroform; Sodium chloride; Undivided cell