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8497048 
Journal Article 
A novel method for synthesis of tetrahydro-2H-oxazolo[2,3-a]isoquinolines 
Dinesha, HE; Sandhya, NC; Mantelingu, K 
2019 
Yes 
Asian Journal of Chemistry
ISSN: 0970-7077
EISSN: 0975-427X 
Chemical Publishing Co. 
31 
2 
403-409 
English 
An efficient and direct method for the synthesis of tetrahydro-2H-oxazolo[2,3-a]isoquinolines is reported. This novel method involves ™3P mediated in situ oxidation of benzyl alcohols to aldehyde followed by acetic acid mediated [3+2] cycloaddition reaction to afford tetrahydro-2H-oxazolo[2,3-a]isoquinolines in one-pot operation with good to excellent yields. Heterocyclic alcohols also underwent the reaction with tetrahydroquinolines at room temperature. © 2018 Chemical Publishing Co. All rights reserved. 
C-H functionalization; Isoquinolines; [3+2] cycloaddition; ™T3P