Health & Environmental Research Online (HERO)


Print Feedback Export to File
8518576 
Journal Article 
Modulating effect of glycyrrhizin on plasma glycoconjugates status in 7, 12- dimethyl benz (a) anthracene induced hamster buccal pouch carcinogenesis 
Kowsalya, R; Vinoth, A; Lakshmipriya, M 
2020 
0 
Plant Archives
ISSN: 0972-5210 
Plant Archives 
20 
2001-2005 
English 
Oral cancer starts in the squamous cells that cover the surfaces of the mouth, tongue, and lips. Cancer of the oral cavity has multifactorial aetiologies and is frequently associated with chewing of betel quid containing tobacco, in addition to smoking and alcohol consumption. Glycoproteins are complex proteins in which both a protein and a carbohydrate are joined together in the covalent linkage. Many functional proteins are released by cells into the blood circulation as glycoproteins. DMBA a potent procarcinogen has been used to develop Oral tumors in the buccal mucosa of golden Syrian hamsters. The levels of plasma glycoconjugates were analyzed using standard colorimetric methods. Glycyrrhizin (45 mg//kg b.w) significantly prevented the tumor formation, tumor volume, and burden in DMBA painted hamsters, which indicates its potent chemopreventive efficacy in experimental oral carcinogenesis. Glycyrrhizin administration to DMBA treated hamsters significantly reduced the levels of glycoconjugates to near normal range. The present study thus explores the modulating effect of Glycyrrhizin in DMBA induced oral cancer. © 2020 Plant Archives. All rights reserved. 
Fucose; Glycoproteins; Glycyrrhizin; Hexosamine; Hexose; Sialic acid