Health & Environmental Research Online (HERO)


Print Feedback Export to File
8538245 
Journal Article 
In-vivo studies on anticancer activity of taxol isolated from an endophytic fungus Pestalotiopsis pauciseta Sacc. VM1 
Vennila, R; Thirunavukkarasu, SV; Muthumary, J 
2010 
3 
4 
30-34 
English 
Breast cancer is one of the leading malignant tumors and the second most prevalent cancer in the world among women. Taxol has been used for effective treatment of a variety of cancers including refractory ovarian cancer, breast cancer, non-small cell lung cancer, AIDS related Kaposi's sarcoma, head and neck carcinoma and other cancer types. The present study investigated for chemopreventive effect of fungal taxol derived from an endophytic fungus, Pestalotiopsis pauciseta Sacc. VM1 isolated from a medicinal plant Tabebuia pentaphylla Hemsl. The enzymic and nonenzymic antioxidants i.e., superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), Vitamin C, Vitamin E, reduced glutathione (GSH) were estimated in control and experimental groups. Lipid Peroxides (LPO), Aspartate Aminotransferase (AST) and Alanine Aminotransferase (ALT) were also evaluated. The results showed that the fungal taxol were found to be effective against 7, 12 dimethyl benz (a) anthracene induced mammary tumors in Sprague Dawley rats. 
Anticancer activity; Breast cancer; DMBA; Fungal taxol; Pestalotiopsis pauciseta