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8547756 
Journal Article 
Modifying effects of annona squamosa linn on glycoconjugates levels in 7, 12-dimethylbenz (A) anthracene (DMBA) induced hamster buccal pouch carcinogenesis 
Suresh, K; Manoharan, S; Vijayaanand, MA; Sugunadevi, G 
2010 
Chk 
Journal of Applied Sciences Research
ISSN: 1816-157X
EISSN: 1819-544X 
6 
8 
973-979 
English 
The present study was examined modifying effects of Annona squamosa on glycoconjugates levels in 7,12-dimethyl benz(a)anthracene (DMBA) induced hamster buccal pouch carcinogenesis. Oral squamosa cell carcinomas were induced in buccal pouches of male golden syrian hamsters by painting with 0.5% DMBA in liquid paraffin three times per week for 14 weeks. Oral administration of aqueous and ethanolic extracts of A. squamosa bark at a dose of 500 mg kg-1 b.w and 300mg kg-1 b.w respectively. The total number of tumors, tumor burden, tumor volume as well as the incidence of tumor was significantly decreased on A.squamosa bark extracts treated hamsters and significantly normalized levels of glycoconjugates in tumor bearing animals. Our results suggest that A. squamosa bark extracts protect the cell surface glycoconjugates during DMBA induced hamster buccal pouch carcinogenesis. © 2010, INSInet Publication. 
Annona squamosa; Dmba; Glycoconjugates; Oral cancer