(4+3) cycloaddition reactions in organic synthesis: Synthesis of Bishomomaprotiline [9,10-dihydro-9-(4-methylaminobutyl)-9,10- Propanoanthracene] | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

8548768

Reference Type

Journal Article

Title

(4+3) cycloaddition reactions in organic synthesis: Synthesis of Bishomomaprotiline [9,10-dihydro-9-(4-methylaminobutyl)-9,10- Propanoanthracene]

Author(s)

Al-Saeedi, A; Karama, U; Sultan, MA; Farooqui, M

Year

2016

Is Peer Reviewed?

Journal

Journal of Chemical and Pharmaceutical Research
ISSN: 0975-7384

Publisher

Journal of Chemical and Pharmaceutical Research

Volume

Issue

Page Numbers

279-284

Language

English

Abstract

The reactions between oxyallyl cations and 9-substituted anthracene to obtain 9,10-dihydro-9,10- propanoanthracene substituted have not yet been studied extensively. For this reason, we used (4+3) cycloaddition reactions of 9-(4-pentenyl)-anthracene with 1,1,3,3-tetrabromoacetone as key step for preparation of a homologue of maprotiline which has been synthesized and developed into a clinically useful drug for the treatment of depressant by Ciba-Geigy research group in Switzerland. Â© 2016, Journal of Chemical and Pharmaceutical Research. All rights reserved.

Keywords

(4+3) Cycloaddition Reactions; 1,1,3,3-Tetrabromoacetone; Homologue; Ludiomil; Oxyallyl Cations