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8550627 
Journal Article 
A combination of paclitaxel and Di allyl sulfide on 7, 12 Dimethyl benz (A) anthracene induced lipid peroxidation and antioxidant system in wistar rats 
Muninathan, N; Malliga, S; Selvakumar, C; Kumar, J 
2012 
5 
SUPPL 2 
190-193 
English 
The effect of paclitaxel along with Di allyl sulfide on 7, 12 Dimethyl benz (a) anthracene (DMBA) induced experimental skin cancer was investigated in wistar rats. Control rats were fed the basal diet throughout the experiment. Four other group received DMBA (5μg in 100ml of acetone) i.p to develop skin tumor and one another group of control rats treated with combination of paclitaxel and Di allyl sulfide. After the tumor induction period administration of paclitaxel and Di allyl sulfide effectively suppressed skin cancer which is revealed by the decrease in the extent of lipid peroxidation with concomitant increase in the activities of enzymatic antioxidants (SOD, CAT and GPx) and non enzymatic antioxidants (Reduced Glutathione, Vitamin C and E) levels when compared to skin cancer bearing animals treated with paclitaxel and Di allyl sulfide alone. It was therefore concluded that the combination of paclitaxel and di allyl sulfide on tumorogenesis might be casually related to its antilipidperoxidation, antioxidant and cytosolic activities that plays an important role in DMBA induced skin cancer. 
Di allyl sulfide; DMBA; Paclitaxel; Skin cancer