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Journal Article 
Modifying effects of Piper longum on cell surface abnormalities in 7, 12-dimethylbenz(A)Anthracene induced hamster buccal pouch carcinogenesis 
Senthil, N; Manoharan, S; Balakrishnan, S; Ramachandran, CR; Muralinaidu, R; Rajalingam, K 
International Journal of Pharmacology
ISSN: 1811-7775 
Asian Network for Scientific Information 
Present study has investigated the modifying effects of ethanolic extract of Piper longum dried fruits (PLDFEE) on cell surface abnormalities in DMBA induced hamster buccal pouch carcinogenesis. DMBA painting in hamster buccal pouch three times per week for 14 weeks resulted in well developed, well differentiated squamous cell carcinoma. An increase in glycoconjugates (protein bound hexose, total sialic acid and fucose) in plasma and buccal mucosa tissues and decrease in erythrocyte membrane glycoconjugates were observed in DMBA painted hamsters as compared to control animals. Oral administration of (PLDFEE) restored the status of glycoconjugates and lipids during DMBA induced oral carcinogenesis. Our results indicate that (PLDFEE) has protected the cell surface and maintained the structural integrity of the cell membranes during DMBA induced hamster buccal pouch carcinogenesis. © 2007 Asian Network for Scientific Information. 
DMBA; Glycoconjugates; Oral cancer