A facile and low solvent preparation of HBA's with absence of formaldehyde impurity by the reduction of aldehydes | Health & Environmental Research Online (HERO)

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HERO ID

8555941

Reference Type

Journal Article

Title

A facile and low solvent preparation of HBA's with absence of formaldehyde impurity by the reduction of aldehydes

Author(s)

Mathur, S; Mathur, P; Singh, AP; Vishwanath, K; Goyal, PK

Year

2012

Is Peer Reviewed?

Journal

Journal of Chemical and Pharmaceutical Research
ISSN: 0975-7384

Volume

Issue

Page Numbers

1231-1234

Language

English

Abstract

Hydroxyl benzyl alcohols (abbreviated customarily as HBA's) are the biological relevant molecules due to their excellent neuroprotective effect and free radical scavenging ability. In addition, 4-HBA exhibits inhibitory effect on tyrosinase activity and melanogenesis and warrantee a potential agent for skin lightening to be used in cosmetic products. An efficient, high purity method amenable to the industrial scale manufacture of HBA's is reported. The present work deals with preparation of HBA's with absence of formaldehyde impurity required in pharmaceutical application by the reduction of aldehydes to the corresponding alcohols using sodium borohydride and ammonium carbonate as simple reducing system.

Keywords

Benzaldehyde; Formaldehyde free; Hydroxyl benzyl alcohols; Reduction; Sodium borohydride-ammonium carbonate