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8562447 
Journal Article 
The interaction of chemical compounds with the functional state of the liver - II. Estimation of changes in D-glucaric acid synthesis as a method for diagnosing exposure to xenobiotics 
Notten, WRF; Henderson, PT 
1977 
Yes 
International Archives of Occupational and Environmental Health
ISSN: 0340-0131
EISSN: 1432-1246 
Springer-Verlag 
38 
3 
209-220 
English 
At the present time, numerous chemicals are known to affect the activities of various hepatic enzymes, which find expression in an altered metabolism of both xenobiotic compounds and normal body constituents. A well-known example of the latter phenomenon is the stimulation of the D-glucuronic acid pathway resulting in an enhanced urinary excretion of D-glucaric acid. The results described in this study indicate that the urinary D-glucaric acid level is not necessarily related to the extent of the drug-metabolizing capacity of the liver. Experiments in which animals are treated with a large number of chemicals under different conditions demonstrate the usefulness of an altered D-glucaric acid excretion in urine as a nonspecific indicator for exposure to exogenous compounds. This conclusion is further supported by the results of investigations in which factory workers with exposure to different chemicals were tested for their urinary D-glucaric acid level. Alterations in the biotransformation of chemical compounds and the D-glucuronic acid pathway, caused by exogenous compounds, formed the subject of the first article. © 1977 Springer-Verlag. 
Biotransformation; D-Glucaric acid; Enzyme induction; Exposure test; Xenobiotic compounds