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8572011 
Journal Article 
Chemopreventive and antilipidperoxidative efficacy of Piper longum (Linn.) on 7,12-dimethylbenz (a) anthracene (DMBA) induced hamster buccal pouch carcinogenesis 
Senthil, N; Manoharan, S; Balakrishnan, S; Ramachandran, CR; Muralinaidu, R 
2007 
Yes 
Journal of Applied Sciences
ISSN: 1812-5654 
Asian Network for Scientific Information 
7 
7 
1036-1042 
English 
Aim of the present study was to find out the chemopreventive efficacy of Piper longum, a plant having diverse medicinal properties, in 7,12-dimethyl benz (a) anthracene (DMBA) induced oral carcinogenesis. The mechanistic pathway for its chemopreventive potential was analysed by measuring lipid peroxidation and antioxidants status in DMBA induced oral cancer. DMBA painting in hamster buccal pouch three times per week for 14 weeks resulted in well developed, well differentiated squamous cell carcinoma. Elevated lipid peroxidation and decline in antioxidants were noticed in tumor bearing hamsters as compared to control animals. Oral administration of ethanolic extract of Piper longum dried fruits (PLEFet) on alternate days to DMBA painting significantly prevented the tumor incidence, volume and burden and restored the status of lipid peroxidation and antioxidants in DMBA painted hamsters. Our results indicate that the dried fruits of P. longum has suppressing effects on cell proliferation, which is probably due to its antilipid peroxidative and antioxidative potential during DMBA induced oral carcinogenesis. © 2007 Asian Network for Scientific Information. 
Antioxidants; DMBA; Lipid peroxidation; Oral cancer