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8580886 
Journal Article 
A guide to plasma membrane solute carrier proteins 
Pizzagalli, MD; Bensimon, A; Superti-Furga, G 
2021 
1 
FEBS Journal
ISSN: 1742-464X
EISSN: 1742-4658 
288 
9 
2784-2835 
WOS:000570417100001 
This review aims to serve as an introduction to the solute carrier proteins (SLC) superfamily of transporter proteins and their roles in human cells. The SLC superfamily currently includes 458 transport proteins in 65 families that carry a wide variety of substances across cellular membranes. While members of this superfamily are found throughout cellular organelles, this review focuses on transporters expressed at the plasma membrane. At the cell surface, SLC proteins may be viewed as gatekeepers of the cellular milieu, dynamically responding to different metabolic states. With altered metabolism being one of the hallmarks of cancer, we also briefly review the roles that surface SLC proteins play in the development and progression of cancer through their influence on regulating metabolism and environmental conditions.