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8581306 
Journal Article 
Review 
Importance of Dietary Phosphorus for Bone Metabolism and Healthy Aging 
Serna, J; Bergwitz, C 
2020 
1 
Nutrients
ISSN: 2072-6643 
12 
10 
English 
33007883 
Inorganic phosphate (Pi) plays a critical function in many tissues of the body: for example, as part of the hydroxyapatite in the skeleton and as a substrate for ATP synthesis. Pi is the main source of dietary phosphorus. Reduced bioavailability of Pi or excessive losses in the urine causes rickets and osteomalacia. While critical for health in normal amounts, dietary phosphorus is plentiful in the Western diet and is often added to foods as a preservative. This abundance of phosphorus may reduce longevity due to metabolic changes and tissue calcifications. In this review, we examine how dietary phosphorus is absorbed in the gut, current knowledge about Pi sensing, and endocrine regulation of Pi levels. Moreover, we also examine the roles of Pi in different tissues, the consequences of low and high dietary phosphorus in these tissues, and the implications for healthy aging. 
Phosphates; Phosphorus, Dietary; Index Medicus; mineralization; absorption; hyperphosphatemia; inorganic phosphate (Pi); dietary phosphorus; paracellular; hypophosphatemia; transcellular; Biological Availability; Bone and Bones -- metabolism; Phosphates -- pharmacokinetics; Phosphorus, Dietary -- pharmacokinetics; Healthy Aging -- drug effects