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8585197 
Journal Article 
Protective effect of kalpaamruthaa on altered glycoprotein component levels and membrane-stability in mammary carcinoma 
Veena, K; Shanthi, P; Sachdanandam, P 
2006 
Asian Network for Scientific Information 
2 
4 
315-329 
English 
The effect of Kalpaamruthaa (KA), a modified indigenous preparation, was studied in DMBA induced mammary carcinoma. Glycoprotein components are a biochemical indicator selectively produced by the neoplastic tissue and released into blood and detected in blood or in other body fluids. ATPases is lipid depended membrane bound enzymes and alterations in membrane lipid environment may affect the activities of ATPases and in turn normal cellular functions. Cancerous animals showed a significant decrease in their body weights and significant increase in tumour weights. The levels of Carcino Embryonic Antigen (CEA) in cancer rats were significantly higher, when compared to that of control rats. The levels of these glycoproteins in cancer animals were significantly increased when compared with control animals. The levels of erythrocyte membrane, liver and kidney ATPases are significantly decreased in cancer condition when compared with control animals. Treatment of KA reverted back the pathologic condition by decreasing the level of above enzymes more effectively than Semecarpus anacardium Linn. Nut milk extract (SA). No significarit changes were observed in drug control animals when compared with control animals in all the above studies. These evidences suggest that the therapeutic efficacy of the KA was increased on amalgamation of Semecarpus anacardium, Emblica officinalis and honey. © Academic Journals Inc., USA. 
ATPases; Carcino embryonic antigen; Emblica officinalis; Glycoproteins; Honey; Mammary cancer; Semecarpus anacardium