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8585767 
Journal Article 
Chemical induced oxidative stress during skin carcinogenesis and its debilitation by aegle marmelos fruit extract 
Agrawal, A; Jahan, S; Verma, P; Goyal, PK 
2010 
3 
486-494 
English 
The principal aim of the present work was to evaluate the chemopreventive effect of hydro-alcoholic extract of the whole plant of Aegle marmelos, in 6-7 weeks old male Swiss albino mice, on two stage process of skin carcinogenesis induced by a single topical application of 7, 12-dimethylbenz (a) anthracene (DMBA) and two weeks later promoted by repeated application of croton oil till the end of experiment (i.e. 16 weeks).The oral administration of A. marmelos at 50 mg/kg/b.wt./day during peri- initiational and post-initiational phases of papillomagenesis significantly inhibited the decrease in reduced glutathione (p ≤ 0.001), catalase (p ≤ 0.001) and proteins (p ≤ 0.001) as well as the increase in lipid peroxidation (p ≤ 0.001) levels in skin and liver of experimental mice while compared to carcinogen treated control. The results from the present study suggest the chemopreventive effect of Aegle marmelos fruit extract in DMBA induced skin papillomagnesis. 
Aegle marmelos; Antioxidant defense system; Chemoprevention; Lipid peroxidation (LPO); Oxidative stress; Reduced Glutathione (GSH)