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8586329 
Journal Article 
Ospemifene, vulvovaginal atrophy, and breast cancer 
Wurz, GT; Soe, LH; Degregorio, MW 
2013 
1 
Maturitas
ISSN: 0378-5122 
Elsevier Ireland Ltd 
74 
3 
220-225 
English 
The incidence and severity of vulvovaginal atrophy (VVA) in postmenopausal breast cancer patients has a significant impact on quality of life. While the etiology of VVA is primarily related to low estrogen levels seen in menopause, women with breast cancer have an added risk of VVA induced by a combination of chemotherapy, hormonal therapy, and menopause. Ospemifene is a new, non-hormonal selective estrogen receptor modulator (SERM) triphenylethylene derivative that is effective in treating VVA in postmenopausal women. Although other SERMs have antagonistic effects on the vagina, ospemifene exerts an estrogen-like effect on the vaginal epithelium. This review will focus on data demonstrating the antiestrogenic activity of ospemifene in several unique breast cancer animal models, and the implications for utilizing ospemifene in patients with breast cancer suffering from VVA. Additional research addressing the expanded use of ospemifene in breast cancer patients is also warranted. © 2012 Elsevier Ireland Ltd. 
Antiestrogen; Breast cancer; Ospemifene; Vulvovaginal atrophy