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8586601 
Journal Article 
Protective effect of quercetin against 7, 12 dimethylbenz (a)-anthracene induced breast cancer in rats 
Santhalakshmi, R; Ramakrishna, YG 
2015 
International Journal of Pharmacy and Technology 
7 
1 
8000-8010 
English 
The present study aimed to analyze the anticancer property of quercetin on inhibition of breast carcinoma induced by 7,12- dimethylbenz(a) anthracene (DMBA) in experimental animals. At the end of experimental period, 100% tumor formation was observed in DMBA induced animals. Quercetin at the dose of 100mg/kg body weight was given orally to DMBA induced animals for 30 days after a palpable tumor was observed in the breast. The serum and mammary tissues of experimental rats were analysed for serum tumor markers and levels of antioxidant enzymes. Quercetin effectively increased the levels of antioxidants in DMBA induced cancerous rats and also reduced the levels of tumor markers on quercetin supplementation. Our results demonstrate that quercetin may perhaps maintain the antioxidant levels and reduce the serum tumor markers thereby exerting chemopreventive potential. © 2015, International Journal of Pharmacy and Technology. All rights reserved. 
Antioxidant; Breast cancer; DMBA; Quercetin