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8586681 
Journal Article 
DMBA induces pancreatic tumorigenesis in rats 
Ren, Y; Hou, XP; Li, D; Li, Y; Zhu, B 
2015 
0 
Shijie Huaren Xiaohua Zazhi
ISSN: 1009-3079 
Baishideng Publishing Group Co 
23 
29 
4700-4705 
Chinese 
AIM: To explore the possibility of pancreatic carcinogenesis induced by 7,12-dimethylbenzanthr acene (DMBA) implantation in Sprague-Dawley (SD) rats. METHODS: Eighty male SD rats were randomly divided into two groups: A and B. DMBA (4 mg/100 g body weight) was implanted into the parenchyma of the rat pancreas in group A (n = 70), while no drugs were implanted into the parenchyma of the pancreas in group B (n = 10). Rats were killed at 2, 4 and 6 mo after operation. The pancreatic tissue samples of rats were fixed in formalin for HE staining and immunohistochemical analysis. RESULTS: The body weight of rats at 5 and 6 mo had significant differences between groups A and B (P = 0.00). In group A, the incidence of leiomyosarcoma was 42.1% at 4 mo and 75% at 6 mo, and the rats were accompanied by cachexia, bloody ascites and metastasis. The incidence of leiomyosarcoma at 6 mo was higher than that at 4 mo (P = 0.037). No pancreatic ductal cell carcinoma occurred. CONCLUSION: DMBA (4 mg/100 g body weight) implantation into the parenchyma o f the p ancrea s o f SD rat s ind uces t he development of pancreatic leiomyosarcoma, and the incid ence of leiomyosarcoma at 6 mo is higher than that at 4 mo. DMBA implantation does not induce pancreatic ductal cell carcinoma. © 2015 Baishideng Publishing Group Inc. All rights reserved. 
Animal model; DMBA; Leiomyosarcoma; Pancreatic tumor