Health & Environmental Research Online (HERO)

Print Feedback Export to File
Journal Article 
Bioremedial impact of Curcuma longa on uterus of pesticide exposed mice 
Kumar, R; Nanda, I; Das, S; Kumar, A; Ali, M; Nath, A; Singh, JK 
International Journal of Research in Ayurveda & Pharmacy
ISSN: 2229-3566 
India being a developing country, nearly 67% of the population strives on livelihood through agriculture. Endosulfan is a pesticide of organochlorine group commonly used in this region. Now a day's herbal medicine were used extensively for treatment of different disease. Curcuma longa is very common herbal medicine used as spice commonly. Thus the present study is designed to evaluate bioremedial effect of Curcuma longa on uterus of endosulfan exposed mice. The control group of mice received distilled water. The 'treatment' groups received Endosulfan 2 mg/kg b.w daily by Gavage method for four weeks followed by four weeks administration of aqueous extract of rhizome of Curcuma longa (200 mg/kgb.w/day). Animals were sacrificed after the scheduled treatment. Endosulfan four weeks administered group show clustered nuclei with degenerated cytoplasm in muscular structure of uterus mainly in stratum basale. Circular muscles were observed in more degenerated condition. Degenerated cytoplasm was observed in glands of uterus. Curcuma longa show restoration in muscular layer of uterus with well-defined myometrium and endometrium. Glands were also observed in restored condition. Thus it is concluded from entire study that endosulfan causes degeneration in endometrium and myometrium layer with degenerated glands. Muscular layer were also degenerated with frequent vacuolization. While Curcuma longa administration causes restoration in endometrial layer and myometrium layer. Glands was also restored in structure to greater extent which indicate that Curcuma longa plays vital role against endosulfan toxicity on uterus and restores normal function of uterus including implantation. 
endometrium; gavage; implantation; myometrium; organochlorine