Health & Environmental Research Online (HERO)


Print Feedback Export to File
8600950 
Journal Article 
Efficacy of Eclipta alba (L.) against sub lethal dose of Endosulfan induced biochemical and haematological alterations in Swiss albino mice 
Singh, T; Singh, A; Nivedita; Singh, SK; Singh, JK 
2014 
1 
International Journal of Pharmaceutical Sciences Review and Research
ISSN: 0976-044X 
27 
2 
216-221 
English 
Eclipta alba (L.) Hassk has important role in the traditional systems of herbal medicine. Its free radical scavenging and antioxidant activity has been reported due to the presence of phenolic and flavonoids compounds. Endosulfan is a chlorinated hydrocarbon pesticide widely used in the field of agriculture and reported to have toxicity to liver, kidneys and blood chemistry of non target organisms including humans. The present study aims to assess the potential of medicinal plant E. alba to counter pesticide Endosulfan induced biochemical and hematological alterations in Swiss albino mice. The RBC count and Hb concentrations showed a statistically very significant decrease (P<0.01) in mice that were orally administered Endosulfan (3 mg/Kg) for two weeks (group-II) and four weeks (group-III). The values of HCT, MCV, MCH and MCHC decreased and were statistically significant (P<0.05) as compared to the control group (group- I). Statistically a very significant (P<0.01) increase in the white blood corpuscles (WBC) count was observed in group-II and group-III. Where Endosulfan treated mice which were post-treated with aqueous leaf extract of E. alba (group-IV) showed recovery as indicated by the values of biochemical and hematological indices. The results indicate the potential of the aqueous leaf extract of E. alba as a therapeutic agent which may be used against Endosulfan induced hematological and biochemical alterations in swiss albino mice. 
Eclipta alba; Endosulfan; Haematology; Swiss albino mice