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8606796 
Journal Article 
Recent Developments on Therapeutic and Diagnostic Approaches for COVID-19 
Majumder, J; Minko, T 
2021 
Yes 
AAPS Journal
ISSN: 1550-7416 
23 
1 
14 
English 
The ongoing pandemic of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has made a serious public health threat worldwide with millions of people at risk in a growing number of countries. Though there are no clinically approved antiviral drugs and vaccines for COVID-19, attempts are ongoing for clinical trials of several known antiviral drugs, their combination, as well as development of vaccines in patients with confirmed COVID-19. This review focuses on the latest approaches to diagnostics and therapy of COVID-19. We have summarized recent progress on the conventional therapeutics such as antiviral drugs, vaccines, anti-SARS-CoV-2 antibody treatments, and convalescent plasma therapy which are currently under extensive research and clinical trials for the treatment of COVID-19. The developments of nanoparticle-based therapeutic and diagnostic approaches have been also discussed for COVID-19. We have assessed recent literature data on this topic and made a summary of current development and future perspectives. 
Antiviral Agents; COVID-19 Vaccines; Index Medicus; convalescent plasma therapy; immunotherapy; antiviral drugs; antiviral vaccines; nanotherapeutics; anti-SARS-CoV-2 antibody; Host-Pathogen Interactions; Predictive Value of Tests; Animals; Immunization, Passive -- adverse effects; Treatment Outcome; Antiviral Agents -- therapeutic use; COVID-19 -- virology; COVID-19 Testing; COVID-19 -- diagnosis; COVID-19 Vaccines -- adverse effects; SARS-CoV-2 -- pathogenicity; SARS-CoV-2 -- drug effects; COVID-19 -- drug therapy; COVID-19 Vaccines -- therapeutic use; COVID-19 -- therapy; Antiviral Agents -- adverse effects