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Citation
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HERO ID
8623889
Reference Type
Journal Article
Title
The Effects of Flavonoids in Cardiovascular Diseases
Author(s)
Ciumarnean, L; Milaciu, MV; Runcan, O; Vesa, SC; Rachisan, AL; Negrean, V; Perne, MG; Donca, VI; Alexescu, TG; Para, I; Dogaru, G
Year
2020
Is Peer Reviewed?
Yes
Journal
Molecules
ISSN:
1420-3049
Volume
25
Issue
18
Page Numbers
4320
Language
English
PMID
32967119
DOI
10.3390/molecules25184320
Web of Science Id
WOS:000581308000001
URL
https://www.proquest.com/scholarly-journals/effects-flavonoids-cardiovascular-diseases/docview/2445972490/se-2?accountid=171501
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Abstract
Flavonoids are metabolites of plants and fungus. Flavonoid research has been paid special attention to in recent times after the observation of their beneficial effects on the cardiovascular system. These favorable effects are exerted by flavonoids mainly due to their antioxidant properties, which result from the ability to decrease the oxidation of low-density lipoproteins, thus improving the lipid profiles. The other positive effect exerted on the cardiovascular system is the ability of flavonoids to produce vasodilation and regulate the apoptotic processes in the endothelium. Researchers suggested that these effects, including their anti-inflammatory function, are consequences of flavonoids' potent antioxidant properties, but recent studies have shown multiple signaling pathways linked to them, thus suggesting that there are more mechanisms involved in the beneficial effect of the flavonoids on the human body. This review aims to present the latest data on the classification of these substances, their main mechanisms of action in the human body, and the beneficial effects on the physiological and pathological status of the cardiovascular system.
Keywords
flavonoids; polyphenols; cardiovascular disease
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