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8624952 
Journal Article 
Optimization of plasticizer for Diclofenac sodium transdermal film: Permeation enhancement 
Rajendra, C; Naveen, M; Anurekha, J; Sanjay, J; Kumar, JA; Gupta, MK 
2011 
4 
SUPPL. 2 
178-180 
English 
The present research work was performed to optimize a plasticizer for enhanced skin permeation of Diclofenac sodium through a transdermal film. Diclofenac sodium was used as a model drug to optimize a plasticizer for enhancing skin permeation. Ten different HPMC (3%w/v) based transdermal films using three different plasticizer in different concentration (20%w/w, 30%w/w, 40%w/w of polymer composition): Propylene glycol, Dibutyle phthalate, Diethyl phthalate were prepared & evaluated for ex-vivo drug release to optimize a plasticizer to increase skin permeation. The ex-vivo permeation of Diclofenac sodium through hairless rat skin was found to show maximum increase to 77.104% in 24 hours with Dibutyle phthalate (20% w/w of dry polymer) over propylene glycol (PG), Di-ethyl phthalate (DEP), Propyline glycol. 
HPMC; In vitro/Ex-vivo release study; Permeation; Transdermal film