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8624979 
Journal Article 
Essential oil from Caesalpinia peltophoroides flowers - Chemical composition and in vitro cytotoxic evaluation 
De Carvalho, BA; Domingos, OS; Massoni, M; Dos Santos, MH; Ionta, M; Lago, JHG; Figueiredo, CR; Matsuo, AL; Soares, MG 
2013 
1 
Natural Product Communications
ISSN: 1934-578X 
Natural Product Incorporation 
THOUSAND OAKS 
8 
5 
683-686 
English 
WOS:000319855200033 
The chemical composition of the essential oil obtained from the flowers of Caesalpinia peltophoroides Benth (Leguminosae) was determined using GC/FID and GC/MS analysis. Twenty-seven compounds were identified, including n -dodecanol (14.2%), n-tetradecanol (19.3%), and n-pentadecanol (5.6%), as well as methyl tetradecanoate (7.4%) and methyl hexadecanoate (12.7%) as main constituents. In vitro the cytotoxic activity of the crude essential oil was evaluated against six cancer cell lines - murine melanoma (B16F10-Nex2), human glioblastoma (U87), cervical carcinoma (HeLa), leukemia (HL-60), colon carcinoma (HCT), and melanoma (A2058). The essential oil had significant cytotoxic activity on U87, HCT, and A2058 cell lines. The IC50 values found were lower than those determined for the positive control, cisplatin, suggesting that the oil could be a source of new antineoplastic agents. 
Caesalpinia peltophoroides; Cytotoxic activity; Essential oil composition