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8625050 
Journal Article 
[Bmim]OH mediated new synthesis 3-(1H-indol-3-yl)acrylonitrile derivatives 
Kesari, C; Kankala, S 
2018 
Deuton-X Ltd 
7 
10 
303-306 
English 
[Bmim]OH mediated new synthesis of 3-(1H-indol-3-yl)acrylonitrile derivatives 6 have been developed by the reaction of diethyl phthalate (1) with ethyl cyanoacetic acid hydrazide (2) to form 3-(1,4-dioxo-3,4-dihydrophthalazin-(1H)-yl)-3-oxopropanenitrile (3). Then compound 3 reacted with indole-3-aldehyde (4) by Knoevenagel condensation to form compound 2-(1,4-dioxo-1,2,3,4-tetrahydrophthalazine-2-carbonyl)-3-(1H-indol-3-yl)acrylonitriles (5). Compounds 5 undergo alkylation with alkylating agents to form 6 with good yields. Compounds 6 could also be synthesized by alkylation of 4 followed by condensation with 3. © 2018 Deuton-X Ltd. All rights reserved. 
Green synthesis; Ionic liquid; [Bmim]OH