US EPA

8627163 

Journal Article 

Antioxidant activity and antimutagenic effect of phenolic compounds in feronia limonia (L) swingle fruit 

Phapale, R; Thakur, SM 

2010 

1 

International Journal of Pharmacy and Pharmaceutical Sciences
ISSN: 2656-0097
EISSN: 0975-1491 

2 

4 

68-73 

English 

Feronia limonia (L.) Swingle fruit is much used in India as a stomachic, diuretic, cardiotonic and tonic to the liver and lungs. In this study, free and bound phenolic compound extracts were obtained by successive extractions of feronia limonia ripe fruit pulp. Total phenolic content was evaluated following Folin-Ciocalteu method; antioxidant activity by the DPPH assay and antimutagenic potential by the Ames test. The phenolic glycoside extract presented higher (229.0 mg/g, GAE) total phenolic contents followed by phenolic ester (37.5 mg/g) and free phenolics (11.0mg/g). Where as the antioxidant activity was 88.7%, 11.8% and 3.8% respectively. Phenolic glycoside extract showed antioxidant activity higher than that of commercial antioxidant Trolox (64.6%) and Butylated hydroxytoluene (83.2%). At 2500 μl/plate a significant antimutagenic effect was shown by phenolic glycoside extract and the order of antimutagenic activity was found phenolic glycosides > phenolic esters > free phenolics. Results indicated good correlation between total phenol content, antioxidant activity and antimutagenic effect. Phenolic glycosides in feronia limonia ripe fruit pulp showed promising antioxidant activity, antimytagenic effect and needs further exploration for their effective use in both modern and traditional system of medicines. 

Antimutagenic effect; Antioxidant activity; Feronia limonia (L.) swingle; Fruits; Total phenolic content