Modulatory efficacy of Phyllanthus Emblica L. Fruit extract in combination with cisplatin on xenobiotic metabolizing enzymes status against oral carcinogenesis model | Health & Environmental Research Online (HERO)

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Citation
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HERO ID

8628238

Reference Type

Journal Article

Title

Modulatory efficacy of Phyllanthus Emblica L. Fruit extract in combination with cisplatin on xenobiotic metabolizing enzymes status against oral carcinogenesis model

Author(s)

Krishnaveni, M; Mirunalini, S

Year

2013

Is Peer Reviewed?

Journal

International Journal of Pharmacy and Pharmaceutical Sciences
ISSN: 2656-0097
EISSN: 0975-1491

Volume

Issue

SUPPL 3

Page Numbers

675-680

Language

English

Abstract

Objective: The aim of our current study is to evaluate the modulatory efficacy of combined therapy on xenobiotic metabolizing enzymes against oral cancer model. Methods: Buccal pouch carcinoma was induced in hamsters by painting with DMBA (0.5% in mineral oil) on the left buccal pouch three times a week for 10 weeks. Results: The results showed that depleted activities of phase II enzymes and significant elevation was observed in the levels of phase I enzymes (cytochrome P450 and b5) in DMBA group of buccal pouch. After supplementation with combination therapy significantly brought back the status to near normal. Conclusion: The data obtained in this study clearly indicate that amla fruit extract shows therapeuti effect against DMBA-induced oral carcinogenesis.

Keywords

7,12-dimetylbenz[a]anthracene (DMBA); Cisplatin; Oral carcinogenesis; Phyllanthus emblica