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8634283 
Journal Article 
Short cytoplasmic sequences serve as retention signals for transmembrane proteins in the endoplasmic reticulum 
Nilsson, T; Jackson, M; Peterson, PA 
1989 
Yes 
Cell
ISSN: 0092-8674
EISSN: 1097-4172 
Elsevier 
58 
4 
707-718 
English 
2527615 
WOS:A1989AM54700013 
The adenoviral transmembrane E3/19K glycoprotein is a resident of the endoplasmic reticulum. Here we show that the last six amino acid residues of the 15-membered cytoplasmic tail are necessary and sufficient for the ER retention. These residues can be transplanted onto the cytoplasmic tail of other membrane-bound proteins such that ER residency is conferred. Deletion analysis demonstrated that no single amino acid residue is responsible for the retention. The identified structural motif must occupy the extreme COOH-terminal position to be functional. An endogenous transmembrane ER protein, UDP-glucuronosyltransferase, also contains a retention signal in its cytoplasmic tail. We suggest that short linear sequences occupying the extreme COOH-terminal position of transmembrane ER proteins serve as retention signals.