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Citation
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HERO ID
8634283
Reference Type
Journal Article
Title
Short cytoplasmic sequences serve as retention signals for transmembrane proteins in the endoplasmic reticulum
Author(s)
Nilsson, T; Jackson, M; Peterson, PA
Year
1989
Is Peer Reviewed?
Yes
Journal
Cell
ISSN:
0092-8674
EISSN:
1097-4172
Publisher
Elsevier
Volume
58
Issue
4
Page Numbers
707-718
Language
English
PMID
2527615
DOI
10.1016/0092-8674(89)90105-0
Web of Science Id
WOS:A1989AM54700013
URL
https://linkinghub.elsevier.com/retrieve/pii/0092867489901050
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Abstract
The adenoviral transmembrane E3/19K glycoprotein is a resident of the endoplasmic reticulum. Here we show that the last six amino acid residues of the 15-membered cytoplasmic tail are necessary and sufficient for the ER retention. These residues can be transplanted onto the cytoplasmic tail of other membrane-bound proteins such that ER residency is conferred. Deletion analysis demonstrated that no single amino acid residue is responsible for the retention. The identified structural motif must occupy the extreme COOH-terminal position to be functional. An endogenous transmembrane ER protein, UDP-glucuronosyltransferase, also contains a retention signal in its cytoplasmic tail. We suggest that short linear sequences occupying the extreme COOH-terminal position of transmembrane ER proteins serve as retention signals.
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