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HERO ID
8637938
Reference Type
Journal Article
Subtype
Review
Title
Hyaluronan in tissue injury and repair
Author(s)
Jiang, D; Liang, J; Noble, PW
Year
2007
Is Peer Reviewed?
Yes
Journal
Annual Review of Cell and Developmental Biology
ISSN:
1081-0706
EISSN:
1530-8995
Book Title
Annual Review of Cell and Developmental Biology
Volume
23
Page Numbers
435-461
Language
English
PMID
17506690
DOI
10.1146/annurev.cellbio.23.090506.123337
Web of Science Id
WOS:000250896200017
Abstract
A hallmark of tissue injury and repair is the turnover of extracellular matrix components. This review focuses on the role of the glycosaminoglycan hyaluronan in tissue injury and repair. Both the synthesis and degradation of extracellular matrix are critical contributors to tissue repair and remodeling. Fragmented hyaluronan accumulates during tissue injury and functions in ways distinct from the native polymer. There is accumulating evidence that hyaluronan degradation products can stimulate the expression of inflammatory genes by a variety of immune cells at the injury site. CD44 is the major cell-surface hyaluronan receptor and is required to clear hyaluronan degradation products produced during lung injury; impaired clearance of hyaluronan results in persistent inflammation. However, hyaluronan fragment stimulation of inflammatory gene expression is not dependent on CD44 in inflammatory macrophages. Instead, hyaluronan fragments utilize both Toll-like receptor (TLR) 4 and TLR2 to stimulate inflammatory genes in macrophages. Hyaluronan also is present on the cell surface of lung alveolar epithelial cells and provides protection against tissue damage by interacting with TLR2 and TLR4 on these parenchymal cells. The simple repeating structure of hyaluronan appears to be involved in a number of important aspects of noninfectious tissue injury and repair that are dependent on the size and location of the polymer as well as the interacting cells. Thus, the interactions between the endogenous matrix component hyaluronan and its signaling receptors initiate inflammatory responses, maintain structural cell integrity, and promote recovery from tissue injury.
Keywords
extracellular matrix; CD44; Toll-like receptors; inflammation; lung injury
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