Synthesis of hyaluronan of distinctly different chain length is regulated by differential expression of Xhas1 and 2 during early development of Xenopus laevis | Health & Environmental Research Online (HERO)

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HERO ID

8642624

Reference Type

Journal Article

Title

Synthesis of hyaluronan of distinctly different chain length is regulated by differential expression of Xhas1 and 2 during early development of Xenopus laevis

Author(s)

Koprunner, M; Mullegger, J; Lepperdinger, G

Year

2000

Is Peer Reviewed?

Journal

Mechanisms of Development
ISSN: 0925-4773

Volume

Issue

Page Numbers

275-278

Language

English

PMID

10640711

DOI

10.1016/s0925-4773(99)00238-5

Web of Science Id

WOS:000085388100014

URL

http://://WOS:000085388100014
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Abstract

The localization of hyaluronan has been determined in tailbud stage embryos of Xenopus laevis using a neurocan-alkaline phosphatase fusion protein. This polysaccharide was located between the germ layers and enriched in mesenchyme, the lumen of the neural tube, the embryonic gut, the hepatic cavity and the heart. A full-length cDNA for a hyaluronan synthase, Xhas2 has been cloned. The expression pattern of Xhas1 and 2 is closely similar to the distribution of hyaluronan in the embryo. Xhas1 produces hyaluronan with a molecular mass of around 40-200 kDa, while the product formed by Xhas2 has a molecular mass above 1 million Da.