Paracetamol decreases steady-state exposure to lamotrigine by induction of glucuronidation in healthy subjects | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

8643963

Reference Type

Journal Article

Title

Paracetamol decreases steady-state exposure to lamotrigine by induction of glucuronidation in healthy subjects

Author(s)

Gastrup, S; Stage, TB; Fruekilde, PBN; Damkier, P

Year

2016

Is Peer Reviewed?

Yes

Journal

British Journal of Clinical Pharmacology
ISSN: 0306-5251
EISSN: 1365-2125

Volume

Issue

Page Numbers

735-741

PMID

26588196

DOI

10.1111/bcp.12840

Web of Science Id

WOS:000372894300016

URL

http://://WOS:000372894300016
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Abstract

Patients receiving lamotrigine therapy frequently use paracetamol concomitantly. While one study suggests a possible, clinically relevant drug-drug interaction, practical recommendations of the concomitant use are inconsistent. We performed a systematic pharmacokinetic study in healthy volunteers to quantify the effect of 4Â day treatment with paracetamol on the metabolism of steady-state lamotrigine.