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HERO ID
8687285
Reference Type
Journal Article
Title
Therapeutic effect of aminocyclohexylpenicillin (ac-pc) against experimental infections in mice
Author(s)
Yamazaki, T; Tsuchiya, K
Year
1970
Is Peer Reviewed?
Yes
Journal
Japanese Journal of Antibiotics
ISSN:
0368-2781
Volume
23
Issue
1
Page Numbers
37-41
Language
English
DOI
10.11553/antibiotics1968b.23.37
Abstract
The therapeutic effectiveness of AC-PC, 6-(1-aminocyclohexanecarboxamide) penicillanic acid, in CF-1/H mice intraperitoneally challenged by penicillin G sensitive as well as resistant strains of Staph. aureus, Strept. Pyogenes, E. coli, Pr. vulgaris and K. pneumoniae is determined by single oral, subcutaneous, intravenous or intraperitoneal administration of the antibiotic, immediately after the challenge. The effective dose (ED50) is calculated on the basis of numbers of deaths for 7 days. AC-PC is very effective against Gram-positive bacterial infection. The antibiotic is also effective against Gram-negative bacterial infection. 1970, Japan Antibiotics Research Association. All rights reserved.
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