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8687459 
Journal Article 
Adaptive increase in δ-aminolevulinic acid synthetase by ethchlorovynol and certain related drugs in the guinea-pig and rabbit 
Dajani, RM 
1971 
0 
Comparative and General Pharmacology
ISSN: 0010-4035 
2 
7 
332-340 
English 
1. 1. Prolonged treatment of guinea-pigs and rabbits with ethchlorovynol, methylparafynol, or ethinamate resulted in an enhancement of the activity of δ-aminolevulinic acid (ALA) synthetase as judged by the increase in the amounts of hepatic ALA, although to different extents. 2. 2. A similar but less pronounced effect was noticed after acute treatment with the drugs. 3. 3. Evidence is produced to support the thesis that the observed enzyme-induction was mainly due to de novo synthesis of enzyme protein and possibly to increased quantities of enzyme substrate. 4. 4. The drugs were not specific in this respect, since they were also capable of enhancing the activity of other enzymes such as glutamic dehydrogenase and glutamic-oxaloacetic transaminase. 1971. 
ALA dehydrase; Cania porcellus; collidine derivative (DDC); drug metabolism; Enzyme induction; enzyme protein synthesis; ethchlorovynol; ethinamate; glutamic dehydrogenase; hypnotics and sedatives; inhibition by DL-penicillamine; inhibition by OLA; methylparafynol; Oryctolagus cuniculus; porphobilinogen; porphyria; transaminase; δ-aminolevulinic acid (ALA); δ-aminolevulinic acid (ALA) synthetase