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HERO ID
869264
Reference Type
Journal Article
Title
Sildenafil and glyceryl trinitrate reduce tactile allodynia in streptozotocin-injected rats
Author(s)
Araiza-Saldaña, CI; Rocha-González, HI; Ambriz-Tututi, M; Castañeda-Corral, G; Caram-Salas, NL; Hong, E; Granados-Soto, V
Year
2010
Is Peer Reviewed?
1
Journal
European Journal of Pharmacology
ISSN:
0014-2999
EISSN:
1879-0712
Volume
631
Issue
1-3
Page Numbers
17-23
Language
English
PMID
20079349
DOI
10.1016/j.ejphar.2010.01.001
Web of Science Id
WOS:000275307100003
Abstract
The possible antiallodynic effect of phosphodiesterase 5 inhibitor sildenafil and nitric oxide donor glyceryl trinitrate as well as the changes in phosphodiesterase 5A2 mRNA expression in dorsal root ganglion and spinal cord of allodynic diabetic rats was assessed. Diabetes was induced by streptozotocin (50mg/kg, i.p.) in male Wistar rats. Streptozotocin injection produced hyperlglycemia, polydipsia, polyphagia and polyuria as well as long-term tactile allodynia (12 weeks) and a reduction of phosphodiesterase 5A2 mRNA expression in spinal cord of diabetic rats. Systemic administration of sildenafil (1-5.6 mg/kg, i.p.) reduced tactile allodynia in a dose-dependent manner in diabetic rats. Likewise, glyceryl trinitrate patches (0.2mg/h) also reduced tactile allodynia in diabetic rats. Moreover, both drugs reversed streptozotocin-induced phosphodiesterase 5A2 mRNA expression reduction. Our results indicate that glyceryl trinitrate and sildenafil reduce tactile allodynia in diabetic rats suggesting that nitric oxide and cyclic GMP supply is an important step in their mechanism of action of these drugs in diabetic animals. Data suggest that nitric oxide donors (as glyceryl trinitrate) and drugs which increase cyclic GMP levels (as sildenafil) could have a role in the pharmacotherapy of tactile allodynia in diabetic patients.
Keywords
Diabetes; Tactile allodynia; Phosphodiesterase 5; Sildenafil
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