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8699056 
Journal Article 
Hyponatremia Treatment Guidelines 2007: Expert Panel Recommendations 
Verbalis, JG; Goldsmith, SR; Greenberg, A; Schrier, RW; Sterns, RH 
2007 
1 
American Journal of Medicine
ISSN: 0002-9343
EISSN: 1555-7162 
120 
11 SUPPL. 1 
S1-S21 
English 
Although hyponatremia is a common, usually mild, and relatively asymptomatic disorder of electrolytes, acute severe hyponatremia can cause substantial morbidity and mortality, particularly in patients with concomitant disease. In addition, overly rapid correction of chronic hyponatremia can cause severe neurologic deficits and death, and optimal treatment strategies for such cases are not established. An expert panel assessed the potential contributions of aquaretic nonpeptide small-molecule arginine vasopressin receptor (AVPR) antagonists to hyponatremia therapies. This review presents their conclusions, including identification of appropriate treatment populations and possible future indications for aquaretic AVPR antagonists. 2007 Elsevier Inc. All rights reserved. 
Antidiuretic hormone; Aquaretics; Hypo-osmolality; Natriuresis; Syndrome of inappropriate antidiuretic hormone secretion; Vasopressin