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8703458 
Journal Article 
Effect of Inhibition of Cholesterol Synthesis on the Secretion of Bile Salts in the Rat 
Alam, NA; Glover, J 
1972 
Yes 
European Journal of Biochemistry
ISSN: 0014-2956
EISSN: 1432-1033 
27 
3 
413-418 
English 
The concentrations of bile acids, cholesterol and phospholipids were determined in fistula bile of rats given oral doses of AY 9944 (trans‐1,4‐bis(2‐chlorobenzylaminomethyl)cyclohexane dihydrochloride] (5 mg/kg body wt) daily for 7 days and in that of controls. Both the cholesterol and bile salt secretions in the fistula bile of the treated rats on a sterolfree diet was 15 to 20% below that of controls. The biliary concentration of phospholipids, on the other hand, was only reduced 7–10% by the drug. The proportion of chenodeoxycholic acid to cholic acid was higher in the dosed animals (1:3.5) compared to controls (1:6) indicating that the drug either directly or indirectly also inhibits the 12α‐hydroxylase step in bile acid synthesis. A lower bile acid pool in the enterohepatic circulation of doses rats would partly explain the previously observed poorer intestinal absorption of retinol by rats given AY 9944. Copyright 1972, Wiley Blackwell. All rights reserved