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8703709 
Journal Article 
Interconversion of lipophilicities from hydrocarbon/water systems into the octanol/water system 
Seiler, P 
1974 
Yes 
European Journal of Medicinal Chemistry
ISSN: 0223-5234
EISSN: 1768-3254 
9 
5 
473-479 
English 
By means of a least square analysis the difference between the logarithms of the partition coefficients in the octanol/water and cyclohexane/water system can be broken up into additive increments I(H) for structural segments. To a first approximation I(H) may be regarded as a measure for hydrogen bonding ability. By virtue of this parameter, the Log P values of the above systems can be interconverted with good accuracy.