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8710386 
Journal Article 
Pharmacological Effects of Humulone on Cats and Rabbits 
Söderberg, U; Wachtmeister, C‐‐ 
1955 
Yes 
Acta Physiologica Scandinavica
ISSN: 0001-6772
EISSN: 1365-201X 
34 
1 
90-98 
English 
13258304 
1. Humulone, a well known constituent of hops has been tested on cats and rabbits. 2. 3 mg humulone/kg body weight injected intravenously into cats produced instantaneously a 100% increase in oxygen consumption, followed by a gradual rise in body temperature. 3. Blood pressure was only slightly affected. The amplitude of respiration was increased and when the body temperature reached a level of 42°C temperature polypnoea appeared. 4. Death from lethal doses of humulone was probably caused by the increased body temperature which could exceed 45°C in the cat. After death the animals rapidly developed an abnormally severe rigor mortis. This effect, which was also seen in curarized cats, is similar to the well‐known action of the dinitrophenols. 5. Large doses of humulone also produced glycosuria and haematuria. 6. Rabbits were more resistant than cats to humulone. 7. Liverless animals were more sensitive to humulone than those with intact liver. 8. The actions of humulone in animals are on the whole very similar to those of usnic acid and dinitrophenols. 1955 Scandinavian Physiological Society