US EPA

8710453 

Journal Article 

Review 

Drug-induced lysosomal lipidosis: Biochemical interpretations 

Blohm, TR 

1978 

1 

Pharmacological Reviews
ISSN: 0031-6997
EISSN: 1521-0081 

30 

4 

593-603 

English 

392547 

The subject matter of this paper is drug-induced phospholipidosis. Briefly, a large number of drugs of diverse pharmacological types, but sharing common chemical features, produce intralysosomal accumulation of phospholipids, which appear in various cell types as membranous whorls and/or crystalloid forms, often are discernible only at the electron microscopic level. Morphologically, these forms resemble the accumulations occuring in genetically determined lysosomal lipid storage diseases. Frequently, but not always, doses far exceeding the effective pharmacologocal dose are required to produce the lipid accumulation. Examples prominent in the literature include anorexics (chlorphentermine, fenfluramine), tricyclic antidepressants (iprindole, maprotiline), cholesterol synthesis inhibitors (triparanol, AY-9944), an antimalarial-antiinflammatory (chloroquine) and a coronary dilator (4,4' bis-(diethylaminoethoxy) hexestrol).