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8715325 
Journal Article 
Niobium pentachloride catalysed ring opening of epoxides 
Gomes Constantino, M; Lacerda Jr, V; Aragão, V 
2001 
1 
Molecules
ISSN: 1420-3049 
6 
9 
770-776 
English 
Epoxide ring opening is a frequently required transformation in Organic Synthesis. In this paper we describe the application of NbCl5 for this purpose using three different substrates. Chlorohydrins, 1,2-diols, products containing solvent residues as well as rearrangement products are obtained, depending on both the substrate structure and reaction conditions. Rationalizations to account for some of the results are suggested. 
1,2-Diols; Chlorohydrins; Epoxides; Niobium pentachloride